Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer
2006
Ribosomal Protein L15 and Gastric Cancer
Sample size: 12
publication
Evidence: moderate
Author Information
Author(s): Wang Hui, Zhao Li-Na, Li Kai-Zong, Ling Rui, Li Xiao-Jun, Wang Ling
Primary Institution: Xijing Hospital, the Fourth Military Medical University
Hypothesis
Is ribosomal protein L15 (RPL15) overexpression associated with cell proliferation in gastric cancer?
Conclusion
RPL15 promotes cell proliferation and may be a potential target for anticancer therapy of gastric cancer.
Supporting Evidence
- RPL15 was found to be highly expressed in gastric cancer tissues.
- Inhibition of RPL15 expression suppressed the growth of gastric cancer cells.
- RPL15 expression did not correlate with cancer progression.
Takeaway
RPL15 is a protein that helps cancer cells grow faster, and stopping it might help treat stomach cancer.
Methodology
The study involved examining RPL15 expression in gastric cancer tissues and cell lines, using techniques like immunohistochemistry and siRNA transfection.
Participant Demographics
Patients with gastric cancer and normal gastric mucosa.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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