The Role of HSP70 in Oral Cancer Prognosis
Author Information
Author(s): Tavassol Frank, Starke Oliver F, Kokemüller Horst, Wegener Gerd, Müller-Tavassol Corinna CM, Gellrich Nils-Claudius, Eckardt André
Primary Institution: Hannover Medical School
Hypothesis
This study aimed to investigate the expression and prognostic significance of highly stress-inducible HSP70 in oral squamous cell carcinoma (OSCC).
Conclusion
The survival of patients with T2 tumors and positive HSP70 expression was significantly higher than that of patients with negative expression, indicating a need for more aggressive treatment for those with low HSP70 levels.
Supporting Evidence
- 63.3% of patients showed positive immunoreactivity for HSP70.
- The survival of patients with T2 tumors and positive HSP70 expression was 8 times higher than that of those with negative expression.
- Positive lymph nodes were identified as a significant prognostic factor.
Takeaway
This study found that patients with a certain type of oral cancer who have a protein called HSP70 in their tumors tend to live much longer than those who don't have it.
Methodology
Immunohistochemical staining for HSP70 was performed on surgical specimens from 61 patients with OSCC, and the expression was evaluated using light microscopy.
Limitations
The study focused only on T2 tumors and may not generalize to other stages of OSCC.
Participant Demographics
49 men and 12 women, aged 35 to 60 years, with a mean age of 50.7 years.
Statistical Information
P-Value
0.009
Confidence Interval
[1.912, 89.354]
Statistical Significance
p = 0.009
Digital Object Identifier (DOI)
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