Hemoglobin Helps Staphylococcus aureus Grow in the Nose
Author Information
Author(s): Pynnonen Melissa, Stephenson Rachel E., Schwartz Kelly, Hernandez Margarita, Boles Blaise R.
Primary Institution: University of Michigan
Hypothesis
Does hemoglobin in nasal secretions promote Staphylococcus aureus nasal colonization?
Conclusion
The presence of hemoglobin in nasal secretions contributes to Staphylococcus aureus nasal colonization.
Supporting Evidence
- Nasal secretions from some individuals significantly increased S. aureus surface colonization.
- Protease treatment of these secretions eliminated their ability to promote colonization.
- Hemoglobin was identified as a key protein promoting S. aureus colonization.
- Hemoglobin reduced the inoculum size necessary for nasal colonization in a rodent model.
- Hemoglobin inhibited expression of the agr quorum sensing system, which is linked to colonization.
- Individuals with hemoglobin in their nasal secretions were more likely to be colonized by S. aureus.
Takeaway
Hemoglobin, a protein found in our nose, helps a germ called Staphylococcus aureus stick around and grow, which can make people sick.
Methodology
Human nasal secretions were collected and analyzed for their ability to promote S. aureus surface colonization in various assays, including a cotton rat model.
Potential Biases
Potential bias in sample selection as participants were from a specific clinic.
Limitations
The study primarily focused on a limited number of subjects and may not represent all populations.
Participant Demographics
20 adult patients from a rhiniology clinic and 10 healthy volunteers.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
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