Oxidative Stress in Bus Maintenance Workers
Author Information
Author(s): Sauvain Jean-Jacques, Setyan Ari, Wild Pascal, Tacchini Philippe, Lagger Grégoire, Storti Ferdinand, Deslarzes Simon, Guillemin Michel, Rossi Michel J, Riediker Michael
Primary Institution: Institute for Work and Health, University of Lausanne + Geneva
Hypothesis
Does exposure to respirable particles cause changes in urinary levels of reducing species in bus maintenance workers?
Conclusion
Exposure to respirable particulate matter leads to increased oxidative stress in bus maintenance workers, as indicated by elevated urinary levels of 8OHdG.
Supporting Evidence
- Urinary levels of 8OHdG increased significantly within each shift for non-smokers.
- The between-day increase in 8OHdG was significantly correlated with organic carbon, NOx, and particulate copper content.
- The within-shift increase in 8OHdG was highly correlated to an increase in urinary reducing capacity.
Takeaway
Bus workers who breathe in certain particles can have more stress in their bodies, which can be seen in their urine.
Methodology
Urine samples were collected from bus depot workers before and after shifts to measure oxidative stress biomarkers and reducing capacity.
Potential Biases
Potential bias from self-reported data on smoking and respiratory problems.
Limitations
The study was limited to male workers and may not generalize to other populations.
Participant Demographics
All male mechanics, with 23 non-smokers and 9 smokers, average age 43.1 years.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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