BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas
1999
BCL10 Mutations in Various Cancers
Sample size: 153
publication
Evidence: low
Author Information
Author(s): Gill S, Broni J, Jefferies S, Osin P, Kovacs G, Maitland N J, Eeles R, Edwards S M, Dyer M J S, Willis T G, Cooper C S
Primary Institution: Institute of Cancer Research
Hypothesis
Does the BCL10 gene play a role in the development of certain cancers?
Conclusion
BCL10 does not appear to play a major role in the development of prostate carcinoma, small-cell lung cancer, head and neck tumors, renal carcinoma, and sarcomas.
Supporting Evidence
- The study screened 81 primary prostate carcinomas for BCL10 mutations.
- 20 squamous cell cancers of the head and neck were also analyzed.
- 15 small-cell lung cancer cell lines were included in the study.
- 24 renal carcinoma cell lines were examined for mutations.
- 13 sarcoma cell lines were tested for BCL10 mutations.
Takeaway
The study looked for changes in a gene called BCL10 in different types of cancer but found none, suggesting it isn't important for these cancers.
Methodology
Single-strand conformation polymorphism (SSCP) analysis was used to screen for mutations in the BCL10 gene across various cancer types.
Digital Object Identifier (DOI)
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