Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases
2006
VEGFR-1 and Colorectal Cancer Cell Migration
publication
Evidence: moderate
Author Information
Author(s): Lesslie D P III, Summy J M, Parikh N U, Fan F, Trevino J G, Sawyer T K, Metcalf C A III, Shakespeare W C, Hicklin D J, Ellis L M, Gallick G E
Primary Institution: The University of Texas MD Anderson Cancer Center
Hypothesis
Does VEGFR-1 activation through Src family kinases mediate migration in colorectal cancer cells?
Conclusion
VEGFR-1 promotes the migration of colorectal cancer cells through a Src-dependent pathway.
Supporting Evidence
- VEGF stimulation resulted in enhanced cellular migration in colorectal cancer cell lines.
- Pharmacologic inhibition of VEGFR-1 or Src kinase blocked VEGF-induced migration.
- Src family kinases were required for VEGF-induced migration in colorectal cancer cells.
Takeaway
This study shows that a protein called VEGFR-1 helps cancer cells in the colon move around, which might make the cancer spread more.
Methodology
The study used human colorectal cancer cell lines to investigate the role of Src family kinases in VEGF-mediated signaling and migration.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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