Gene Expression Patterns in Larval Schistosoma mansoni Associated with Infection of the Mammalian Host
Author Information
Author(s): Parker-Manuel Sophia J., Ivens Alasdair C., Dillon Gary P., Wilson R. Alan
Primary Institution: University of York
Hypothesis
What are the gene expression patterns in Schistosoma mansoni during its transition from larval stages to infection in mammalian hosts?
Conclusion
The study reveals that many genes involved in skin invasion are activated early in the life cycle of Schistosoma mansoni, particularly during the transition from cercaria to schistosomulum.
Supporting Evidence
- Genes necessary for DNA replication were enriched only in the germ ball stage.
- Different sets of developmental genes were up-regulated at each stage of the life cycle.
- A large number of genes encoding elastases and invadolysins were up-regulated in the germ ball.
Takeaway
This study looks at how a tiny worm changes its genes when it tries to infect a mammal. It finds that many important genes are turned on right away to help the worm get inside.
Methodology
The study used a high-density oligonucleotide array to analyze gene expression in different life stages of Schistosoma mansoni.
Limitations
The study may not account for all environmental factors affecting gene expression during infection.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website