Spontaneous inactivating p53 mutations and the 'selfish cell'
2011
How to Become Immortal: Let MEFs Count the Ways
Commentary
Author Information
Author(s): Sorscher Steven M., Hill Aubrey E., Belizaire Roger, Sorscher Eric J.
Hypothesis
Cells seek to survive in a Darwinian sense, leading to tumorigenesis through spontaneous p53 mutations.
Conclusion
Spontaneous mutations in p53 that allow cell survival may contribute to tumorigenesis, supporting the 'Selfish Cell Theory'.
Supporting Evidence
- Murine embryo fibroblasts undergo p53 mutations and immortalizations in culture.
- Spontaneous mutations in p53 are frequently seen in human cancers.
- The 'Selfish Cell Theory' suggests that cells evolve to survive, even at the cost of tumorigenesis.
Takeaway
Some cells can change in a way that helps them live longer, which can also lead to cancer.
Want to read the original?
Access the complete publication on the publisher's website