Persistence of Phi6, a SARS-CoV-2 surrogate, in simulated indoor environments: Effects of humidity and material properties
2025

How Humidity Affects Virus Survival on Surfaces

publication 10 minutes Evidence: moderate

Author Information

Author(s): Parry-Nweye Eloise, Liu Zhenlei, Dhaouadi Yousr, Guo Xin, Huang Wenfeng, Zhang Jianshun, Ren Dacheng

Primary Institution: Syracuse University

Hypothesis

How does humidity influence the persistence of viruses on fomites in indoor environments?

Conclusion

Higher humidity levels can significantly reduce the infectivity of aerosolized viruses on surfaces, with a notable V-shaped relationship observed.

Supporting Evidence

  • The infectivity of aerosolized Phi6 decreased by ≥ 1 log10 as humidity increased from 25% to 75%.
  • At 85% humidity, the infectivity increased again, creating a V-shaped curve.
  • Material properties impact viral persistence, but humidity has a more significant effect.

Takeaway

This study shows that viruses can survive longer on surfaces in dry conditions, but too much humidity can make them less infectious.

Methodology

The study used a full-scale environmental chamber to test the effects of different humidity levels on the infectivity of aerosolized Phi6.

Limitations

The study used Phi6 as a surrogate for SARS-CoV-2, which may not fully replicate the behavior of the actual virus.

Statistical Information

P-Value

<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0313604

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