The Role of CCR5 in HIV Infection
Author Information
Author(s): Janet M. McNicholl, Dawn K. Smith, Shoukat H. Qari, Thomas Hodge
Primary Institution: Centers for Disease Control and Prevention
Hypothesis
Does the CCR5 32 bp deletion provide absolute protection against HIV infection?
Conclusion
The CCR5 gene polymorphism influences susceptibility to HIV infection and the progression of the disease.
Supporting Evidence
- 22.6 million people are infected with HIV as of mid-1996.
- Certain distributions of HLA class I alleles were observed in uninfected female commercial sex workers in Africa.
- The 32 bp deletion in the CCR5 gene has been associated with resistance to HIV infection.
Takeaway
Some people have a gene that can help protect them from getting HIV, but it's not a guarantee. Even those with this gene can still get the virus.
Methodology
The study examined the role of the CCR5 chemokine receptor gene in HIV susceptibility and disease progression.
Limitations
The study does not provide a definitive answer on the absolute protection against HIV for those with the CCR5 32 bp deletion.
Participant Demographics
The study includes various populations, primarily focusing on Caucasians and other ethnic groups in different geographical locations.
Want to read the original?
Access the complete publication on the publisher's website