Protein Analysis of Arachnoid Cyst Fluid
Author Information
Author(s): Berle Magnus, Kroksveen Ann C, Haaland Øystein A, Aye Thin T, Opsahl Jill A, Oveland Eystein, Wester Knut, Ulvik Rune J, Helland Christian A, Berven Frode S
Primary Institution: University of Bergen
Hypothesis
Arachnoid cyst fluid is a homogenous condition with a similar protein profile across different patients.
Conclusion
The study found that temporal arachnoid cyst fluid is homogenous and has a protein content similar to cerebrospinal fluid.
Supporting Evidence
- The study identified 199 proteins in arachnoid cyst fluid.
- 15 proteins in AC fluid were not found in cerebrospinal fluid or plasma databases.
- Most proteins identified in AC fluid were also found in cerebrospinal fluid.
Takeaway
The fluid from arachnoid cysts is similar to the fluid that surrounds the brain, and it looks pretty much the same in different people.
Methodology
Proteomics analysis of arachnoid cyst fluid from 15 patients using LC-MS/MS and comparison with cerebrospinal fluid and plasma protein databases.
Limitations
The study did not explore the quantitative differences between AC fluid and CSF.
Participant Demographics
15 patients (6 male, 9 female, ages 22-77) with unilateral temporal arachnoid cysts.
Digital Object Identifier (DOI)
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