The Role of ROMO1 in Gastrointestinal Cancers
Author Information
Author(s): Yaman Selçuk, Akidan Osman, Vatansever Mehmet, Misir Sema, Yaman Serap Ozer
Primary Institution: Trabzon Kanuni Training and Research Hospital
Hypothesis
This study aims to reveal the expression change and oncogenic role of ROMO1 in gastrointestinal system cancers.
Conclusion
ROMO1 is significantly upregulated in gastrointestinal cancers and is associated with clinicopathological features, suggesting its potential as a diagnostic and therapeutic target.
Supporting Evidence
- ROMO1 expression is significantly increased in COAD, ESCA, LIHC, and PAAD.
- High expression of ROMO1 is associated with poor overall survival in LIHC.
- ROMO1 is closely related to immune cell infiltration in gastrointestinal cancers.
Takeaway
ROMO1 is a protein that helps cancer cells grow, and studying it can help doctors find better ways to treat stomach and intestinal cancers.
Methodology
Bioinformatics analyses were conducted using databases like GEPIA, UALCAN, TIMER, and STRING to assess ROMO1 expression and its association with various gastrointestinal cancers.
Limitations
The study is limited by the need for larger sample sizes and the necessity for in vivo and in vitro experimental confirmation of ROMO1's role.
Statistical Information
P-Value
0.038
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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