Probiotics Promote Longevity in Mice
Author Information
Author(s): Matsumoto Mitsuharu, Kurihara Shin, Kibe Ryoko, Ashida Hisashi, Benno Yoshimi
Primary Institution: Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd., Tokyo, Japan
Hypothesis
The use of probiotics such as LKM512 would increase mammalian longevity by suppressing chronic low-grade inflammation.
Conclusion
The study demonstrated increased longevity in mice following probiotic treatment with LKM512, possibly due to the suppression of chronic low-grade inflammation in the colon induced by higher polyamine levels.
Supporting Evidence
- LKM512-treated mice survived significantly longer than controls.
- Skin ulcers and tumors were more common in the control mice.
- LKM512 administration downregulated the expression of ageing-associated and inflammation-associated genes.
- Fecal concentrations of polyamines were significantly higher in LKM512-treated mice.
- LKM512 administration improved colonic mucosal function.
Takeaway
Feeding mice a special probiotic helped them live longer and healthier by reducing inflammation in their guts.
Methodology
10-month-old female mice were supplemented with LKM512 for 11 months, and survival rates were compared using Kaplan–Meier survival curves.
Limitations
Further studies are required to clarify its effectiveness in humans.
Participant Demographics
10-month-old female Crj:CD-1 mice.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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