Factors Linked to Dry Eye Disease
Author Information
Author(s): Yang Kuiliang, Wu Shangcao, Ke Lan, Zhang Han, Wan Shanshan, Lu Mingzhi, Mao Jiewen, Gao Yuelan, Yang Yanning, Xing Yiqiao, Yang Wanju
Primary Institution: Aier Eye Hospital of Wuhan University, Wuhan, China
Hypothesis
This study aimed to conduct a meta-analysis on potential risk factors for dry eye disease.
Conclusion
The study found that various factors, including smoking, alcohol consumption, and psychological conditions, are associated with an increased risk of dry eye disease.
Supporting Evidence
- Smoking was associated with a 1.18 times increased risk of dry eye disease.
- Alcohol consumption also showed a 1.18 times increased risk.
- Psychological conditions like anxiety and depression were significant risk factors.
Takeaway
This study looked at what might cause dry eye disease and found that things like smoking and stress can make it worse.
Methodology
A systematic review and meta-analysis were conducted using observational studies from multiple databases, extracting adjusted odds ratios and confidence intervals.
Potential Biases
Potential publication bias was noted for some associations, particularly with diabetes and stress.
Limitations
The sample sizes of included studies varied greatly, and only English-language publications were included.
Participant Demographics
The mean age of participants ranged from 7.5 to 82.2 years, with a total of 11,732,821 individuals included.
Statistical Information
P-Value
0.0358 for diabetes, 0.0408 for stress
Confidence Interval
1.07–1.29 for smoking, 1.03–1.35 for alcohol, 1.96 for rosacea, 4.59 for allergic conjunctivitis, etc.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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