Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice
1999
Interleukin-8 Boosts Tumor Growth in Stomach Cancer
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): Kitadai Y, Takahashi Y, Haruma K, Naka K, Sumii K, Yokozaki H, Yasui W, Mukaida N, Ohmoto Y, Kajiyama G, Fidler I J, Tahara E
Primary Institution: Hiroshima University School of Medicine
Hypothesis
Does interleukin-8 play a causal role in angiogenesis and tumorigenicity of human gastric cancer?
Conclusion
Interleukin-8 promotes the growth and vascularization of gastric tumors in mice.
Supporting Evidence
- IL-8 expression correlates with the vascularity of human gastric carcinomas.
- IL-8-transfected cells produced rapidly growing, highly vascular neoplasms in mice.
Takeaway
This study found that a substance called interleukin-8 helps stomach cancer cells grow and form new blood vessels.
Methodology
The study involved transfecting gastric carcinoma cells with an IL-8 expression vector and injecting them into nude mice.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website