Cytotoxicity and Antimicrobial Effects of Endodontic Sealers
Author Information
Author(s): Willershausen Ines, Callaway Angelika, Briseño Benjamin, Willershausen Brita
Primary Institution: University Medical Centre of the Johannes Gutenberg University Mainz, Germany
Hypothesis
This study aimed to investigate the cytotoxicity and antibacterial properties of four different endodontic sealers.
Conclusion
GuttaFlow and EndoSequence BC are biocompatible sealing materials, while Pulp Canal Sealer EWT and AH Plus Jet showed significant cytotoxicity.
Supporting Evidence
- GuttaFlow and EndoSequence BC showed relatively non-cytotoxic reactions.
- Pulp Canal Sealer EWT and AH Plus Jet caused a significant decrease in cell proliferation.
- No antibacterial effect of EndoSequence BC against P. micra was found.
- GuttaFlow showed a weak antibacterial effect against P. micra.
Takeaway
The study tested four types of dental sealers to see how they affect cells and bacteria. Some sealers are safer for cells than others.
Methodology
The study used human periodontal ligament fibroblasts to assess cell proliferation and visual analysis of growth inhibition after exposure to different sealers.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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