Effectiveness of Influenza Vaccines in HIV-Infected Individuals
Author Information
Author(s): Atashili Julius, Kalilani Linda, Adimora Adaora A
Primary Institution: University of North Carolina, Chapel Hill
Hypothesis
What is the efficacy and clinical effectiveness of influenza vaccines in HIV-infected individuals?
Conclusion
Influenza vaccines are moderately effective in reducing the incidence of influenza in HIV-infected individuals.
Supporting Evidence
- Four studies showed lower incidence of influenza in vaccinated HIV-infected individuals compared to unvaccinated.
- Vaccine effectiveness ranged from 27% to 78%.
- A random effects model yielded a summary risk difference of -0.27.
Takeaway
Getting a flu shot can help people with HIV get sick less often from the flu.
Methodology
A meta-analysis of studies comparing influenza incidence in vaccinated versus unvaccinated HIV-infected individuals.
Potential Biases
Potential selection bias and confounding due to the non-randomized nature of most studies.
Limitations
The number of studies was limited, and most were not randomized, which may affect the generalizability of the results.
Participant Demographics
The studies involved 646 HIV-infected individuals, predominantly male (82%), aged 20 to 78 years.
Statistical Information
P-Value
0.003
Confidence Interval
95% CI: -0.42, -0.11
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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