FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines
2001
FGF-1 and FGF-2 in Pancreatic Cancer
Sample size: 3
publication
Evidence: moderate
Author Information
Author(s): EI-Hariry I, Pignatelli M, Lemoine N R
Primary Institution: Imperial Cancer Research Fund Molecular Oncology Unit
Hypothesis
FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines.
Conclusion
FGF-1 and FGF-2 enhance cell adhesion and reduce invasion in pancreatic cancer cells.
Supporting Evidence
- FGF-1 and FGF-2 lead to significant increases in E-cadherin-dependent cell-cell adhesion.
- FGF stimulation results in phosphorylation of E-cadherin and β-catenin.
- FGF-1 and FGF-2 are associated with increased E-cadherin localization to the cytoplasmic membrane.
Takeaway
This study found that certain growth factors help pancreatic cancer cells stick together better and invade less.
Methodology
The effects of FGF-1 and FGF-2 were investigated on human pancreatic adenocarcinoma cell lines.
Digital Object Identifier (DOI)
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