CALM1 Gene and Knee Osteoarthritis in Chinese Han Population
Author Information
Author(s): Shi Dongquan, Ni Haijian, Dai Jin, Qin Jianghui, Xu Yong, Zhu Lunqing, Yao Chen, Shao Zhenxing, Chen Dongyang, Xu Zhihong, Yi Long, Ikegawa Shiro, Jiang Qing
Primary Institution: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University
Hypothesis
Is the CALM1 core promoter polymorphism (-16C/T) associated with knee osteoarthritis susceptibility in a Chinese Han population?
Conclusion
The study found no association between the CALM1 core promoter polymorphism -16C/T and knee osteoarthritis susceptibility in the Chinese Han population.
Supporting Evidence
- No significant difference was detected in genotype or allele distribution between knee OA and control groups.
- The association was negative even after stratification by sex.
- No association was found between the -16C/T SNP genotype and clinical variables in OA patients.
Takeaway
The researchers looked at a gene to see if it affects knee arthritis in Chinese people, but they found it doesn't.
Methodology
A case-control association study with 183 knee OA patients and 210 matched controls was conducted, comparing genotype and allele frequencies.
Limitations
The study may have been limited by a relatively small sample size and the focus on a specific population.
Participant Demographics
183 patients (124 women, 59 men) with knee OA and 210 controls (142 women, 68 men), all Han Chinese.
Statistical Information
P-Value
0.996 for allele frequency, 0.802 for genotype frequency
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website