Normal Tissue Damage from Photodynamic Therapy in Pigs
Author Information
Author(s): Murrer L H P, Hebeda K M, Marijnissen J P A, Star W M
Primary Institution: Department of Clinical Physics, Dr Daniel Den Hoed Cancer Centre, Rotterdam, The Netherlands
Hypothesis
The study evaluates the damage to normal pig bronchial mucosa caused by photodynamic therapy using different photosensitizers.
Conclusion
Photodynamic therapy with Photofrin caused significant damage to pig bronchial mucosa, while mTHPC caused only slight damage.
Supporting Evidence
- Photofrin caused considerable damage to the mucosa with oedema and blood vessel damage.
- mTHPC caused slight damage with fluences of 12.5–50 J cm−2.
- Damage was confined to the mucosa and submucosa, leaving cartilage intact.
- Long-term recovery was observed within 14 days for both treatments.
Takeaway
This study looked at how two treatments affect the lungs of pigs, finding that one treatment caused more harm than the other.
Methodology
The study used an endobronchial applicator to deliver light and measure fluence in situ, varying fluences based on clinical protocols.
Limitations
Limited data on pharmacokinetics of mTHPC and inter-animal variations in fluence rate.
Participant Demographics
Pigs were used as the model organism for the study.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website