Remnant Cholesterol and Gestational Diabetes Risk
Author Information
Author(s): Sheng Jing, Ma Chun-Fang, Wu Xiao-Fei, Li Xiang-Xiang
Primary Institution: Suzhou Ninth People's Hospital Affiliated to Soochow University
Hypothesis
The RC/HDL-C ratio in early pregnancy may be correlated with the diagnosis of gestational diabetes mellitus (GDM).
Conclusion
Higher levels of the RC/HDL-C ratio between 12 and 14 weeks of gestation are associated with an increased risk of GDM, independent of traditional risk factors.
Supporting Evidence
- The RC/HDL-C ratio was a robust predictor of GDM.
- The area under the ROC curve for the RC/HDL-C ratio was 0.795.
- The optimal threshold value for the RC/HDL-C ratio was 0.45.
Takeaway
This study found that a specific cholesterol ratio in pregnant women can help predict the risk of developing diabetes during pregnancy.
Methodology
This was a secondary analysis of data from a Korea-based prospective cohort study involving 582 women examined between November 2014 and July 2016.
Potential Biases
Potential confounding factors such as dietary intake and physical activity levels were not controlled.
Limitations
The study's sample size was small and limited to a specific population, which may affect generalizability.
Participant Demographics
The average age of participants was 32.07 years, with a prevalence of GDM at 6.01%.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI: 3.55–133.73
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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