Frizzled 3 Gene and Methamphetamine Psychosis
Author Information
Author(s): Kishimoto Makiko, Ujike Hiroshi, Okahisa Yuko, Kotaka Tatsuya, Takaki Manabu, Kodama Masafumi, Inada Toshiya, Yamada Mitsuhiko, Uchimura Naohisa, Iwata Nakao, Sora Ichiro, Iyo Masaomi, Ozaki Norio, Kuroda Shigetoshi
Primary Institution: Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Hypothesis
Is there an association between the Frizzled 3 gene and susceptibility to methamphetamine psychosis?
Conclusion
Genetic variants of the FZD3 gene affect susceptibility to both schizophrenia and methamphetamine psychosis.
Supporting Evidence
- Two FZD3 haplotypes were identified as negative risk factors for methamphetamine psychosis.
- The study included a large sample size of 188 patients and 240 controls.
- Genetic variants of FZD3 were previously associated with schizophrenia.
Takeaway
The study found that certain genetic patterns in the FZD3 gene can make people more or less likely to experience psychosis from methamphetamine use.
Methodology
The study analyzed six SNPs of the FZD3 gene in 188 patients with methamphetamine psychosis and 240 matched controls.
Limitations
The study may have less power for haplotype analyses due to sample size.
Participant Demographics
188 patients (158 male, 30 female; mean age 36.6) and 240 controls (192 male, 48 female; mean age 36.6), all unrelated Japanese.
Statistical Information
P-Value
p < 0.00001
Confidence Interval
0.07–0.22 for G-A-T-G; 0.03–0.24 for A-G-C-A
Statistical Significance
p < 0.00001
Digital Object Identifier (DOI)
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