Alzheimer's Disease and Spirochetes
Author Information
Author(s): Judith Miklossy
Primary Institution: International Alzheimer Research Center, Prevention Alzheimer Foundation, Martigny-Combe, Switzerland
Hypothesis
Could various types of spirochetes be involved in the pathogenesis of Alzheimer's disease?
Conclusion
There is a statistically significant association between spirochetes and Alzheimer's disease, suggesting a probable causal relationship.
Supporting Evidence
- More than 90% of Alzheimer's cases analyzed showed the presence of spirochetes in the brain.
- Borrelia burgdorferi was found in 25.3% of Alzheimer's cases, significantly more than in controls.
- Chronic spirochetal infection can cause dementia, brain atrophy, and amyloid deposition.
Takeaway
This study suggests that certain bacteria might be linked to Alzheimer's disease, and treating these infections could help prevent dementia.
Methodology
The study reviewed literature and analyzed data on the presence of spirochetes in Alzheimer's patients compared to controls.
Potential Biases
Potential publication bias in studies showing positive associations between spirochetes and Alzheimer's.
Limitations
The study relies on existing literature, which may have varying methodologies and sample sizes.
Participant Demographics
The study included 247 Alzheimer's disease cases and 77 controls.
Statistical Information
P-Value
1.5 × 10-17
Confidence Interval
95% CI = 8-60
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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