Identifying a New Biomarker for Encephalopathy in Children
Author Information
Author(s): Asano Takeshi, Koizumi Shinya, Takagi Atsushi, Hatori Takayuki, Kuwabara Kentaroh, Fujino Osamu, Fukunaga Yoshitaka
Primary Institution: Nippon Medical School, Chiba Hokusoh Hospital
Hypothesis
Can a novel protein marker be identified in the cerebrospinal fluid of children with acute encephalopathy?
Conclusion
The study identified a 4.8-kDa peptide from the neurosecretory protein VGF as a potential biomarker for encephalopathy.
Supporting Evidence
- The 4.8-kDa peptide was significantly reduced in patients with encephalopathy compared to those with febrile seizures.
- SELDI-TOF MS technology was used to analyze cerebrospinal fluid samples.
- Expression of VGF4.8 is decreased in other degenerative brain conditions.
Takeaway
Researchers found a tiny protein that could help doctors tell if kids have a serious brain problem called encephalopathy.
Methodology
Cerebrospinal fluid samples were analyzed using SELDI-TOF mass spectrometry to identify protein markers.
Potential Biases
Potential bias in diagnosis as it relied on clinical findings and routine examinations.
Limitations
The study had a small sample size and focused only on specific types of encephalopathy.
Participant Demographics
Children with acute encephalopathy and febrile seizures, with no significant differences in age or other clinical parameters.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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