Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression
2011
Dynamin Inhibitors Induce Cell Death in Cancer Cells
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Joshi Sanket, Braithwaite Antony W, Robinson Phillip J, Chircop Megan
Primary Institution: Children's Medical Research Institute, The University of Sydney
Hypothesis
MiTMABs induce apoptosis following cytokinesis failure in cancer cells.
Conclusion
MiTMAB-induced apoptosis is dependent on polyploidization and specific intracellular signaling components.
Supporting Evidence
- MiTMABs induce cell death specifically following cytokinesis failure via the intrinsic apoptotic pathway.
- Apoptosis was blocked by the pan-caspase inhibitor, ZVAD.
- HeLa cells stably expressing Bcl-2 were resistant to MiTMAB-induced cell death.
- MiTMABs induce apoptosis in a concentration-dependent manner.
Takeaway
The study shows that a new type of cancer drug can make cancer cells die by messing up their division process.
Methodology
The study used various cancer cell lines and assessed cell death through flow cytometry and time-lapse microscopy.
Limitations
The study primarily focused on specific cancer cell lines and may not generalize to all cancer types.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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