TLR4 Gene Polymorphisms and Normal Tension Glaucoma
Author Information
Author(s): Suh Wool, Kim Sungmin, Ki Chang-Seok, Kee Changwon
Primary Institution: Samsung Medical Center, Sungkyunkwan University School of Medicine
Hypothesis
Are Toll-like receptor 4 (TLR4) gene polymorphisms associated with normal tension glaucoma (NTG) in the South Korean population?
Conclusion
TLR4 single nucleotide polymorphisms are not associated with normal tension glaucoma.
Supporting Evidence
- Allele frequencies of TLR4 SNPs did not show significant differences between NTG patients and controls.
- Genotype and haplotype analyses also revealed no significant associations.
- Study findings suggest TLR4 polymorphisms may not play a role in NTG pathogenesis.
Takeaway
The study looked at whether certain genes are linked to a type of eye disease called normal tension glaucoma, but found no connection.
Methodology
147 NTG patients and 380 healthy controls were genotyped for 8 TLR4 SNPs.
Potential Biases
Potential biases in participant selection and differences in study design compared to previous research.
Limitations
The study may not represent all populations due to differences in genetic backgrounds and selection criteria.
Participant Demographics
147 NTG patients and 380 healthy controls, all South Korean adults.
Statistical Information
P-Value
p>0.00625
Statistical Significance
p>0.00625
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