Modulation of cis-diamminedichloroplatinum(II) resistance: a review
1992
Review of CDDP Resistance Modulation
publication
Evidence: moderate
Author Information
Author(s): H. Timmer-Bosscha, N.H. Mulder, E.G.E. de Vries
Primary Institution: University Hospital, Groningen, The Netherlands
Hypothesis
What agents can be used to overcome cis-diamminedichloroplatinum(II) resistance in cancer treatment?
Conclusion
Various agents can potentially modulate CDDP resistance, enhancing its cytotoxic effects in resistant cancer cells.
Supporting Evidence
- Hyperthermic treatment can restore CDDP accumulation in resistant cell lines.
- Calcium channel blockers and calmodulin inhibitors have inconsistent effects on CDDP resistance.
- Glutathione is a promising target for modulating cytoplasmic defense mechanisms against CDDP.
Takeaway
This study looks at different ways to help cancer drugs work better by overcoming resistance in cancer cells.
Methodology
The review summarizes various agents and their mechanisms that can modulate CDDP resistance in vitro and in vivo.
Limitations
The review does not provide new experimental data but summarizes existing literature.
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