Effects of L-Ornithine on Mental Stress and Fatigue
Author Information
Author(s): Moriyasu Kazuki, Nakajima Atsushi, Morita Masahiko
Primary Institution: Institute of Health Sciences, Kirin Holdings Company, Limited
Hypothesis
L-ornithine oral administration could relieve stress and improve mental-stress-related fatigue and mood status.
Conclusion
L-ornithine could potentially improve interpersonal social-stress-associated fatigue without involving the HPA axis.
Supporting Evidence
- L-ornithine significantly improved fatigue and anger scores compared to placebo.
- Salivary cortisol levels did not differ significantly between the L-ornithine and placebo groups.
- The study was randomized, double-blind, and placebo-controlled.
Takeaway
This study looked at whether taking L-ornithine can help people feel less tired and stressed after social situations. It found that while it didn't lower stress hormones, it did help with feelings of fatigue and anger.
Methodology
Participants were randomly assigned to receive either 1600 mg of L-ornithine or a placebo for 7 days, followed by the Trier Social Stress Test.
Potential Biases
Potential bias due to the small sample size and participant selection criteria.
Limitations
No significant difference was observed in salivary cortisol levels, the primary endpoint, and the study did not analyze blood ammonia profiles after stress.
Participant Demographics
Healthy Japanese adults aged 20 to 60, with a mix of men and women.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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