Editorial: Extracellular vesicles: emerging roles in the aged and neurodegenerative brain
2024
Extracellular Vesicles in the Aged and Neurodegenerative Brain
Editorial
Author Information
Author(s): Vasilopoulou Foteini, Pocock Jennifer, Bitan Gal, Hermann Dirk M.
Primary Institution: UCL Queen Square Institute of Neurology, University College London
Conclusion
Extracellular vesicles (EVs) play significant roles in neuroinflammation and neurodegenerative diseases, with potential as biomarkers and therapeutic targets.
Supporting Evidence
- EVs are released by virtually all cells in the CNS and PNS and carry a heterogeneous cargo that reflects the state of their parent cells.
- Reactive sEVs induce the secretion of proinflammatory cytokines and chemokines in naïve slices.
- Serum-free astrocytes are more akin to in vivo human resting astrocytes, while serum-cultured astrocytes resemble reactive astrocytes.
- Exosomes have shown neurorestorative and neuroprotective effects in preclinical models of traumatic brain injury and stroke.
Takeaway
Tiny bubbles called extracellular vesicles help brain cells talk to each other and can be important for understanding and treating brain diseases.
Digital Object Identifier (DOI)
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