Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas
1999
PTEN Gene Mutations in Gliomas
Sample size: 46
publication
Evidence: moderate
Author Information
Author(s): Davies M P A, Gibbs F E M, Halliwell N, Joyce K A, Roebuck M M, Rossi M L, Salisbury J, Sibson D R, Tacconi L, Walker C
Primary Institution: JK Douglas Cancer Research Laboratory, Clatterbridge Hospital
Hypothesis
Is mutation in the PTEN gene associated with the grade of gliomas?
Conclusion
PTEN mutations are found exclusively in high grade gliomas and may be linked to the transition from low to high histological grade.
Supporting Evidence
- PTEN mutations were found exclusively in high grade gliomas.
- Eleven genetic variants in ten tumors were identified.
- PTEN mutations were present in 36% of glioblastomas.
Takeaway
The study found that changes in the PTEN gene only happen in more serious types of brain tumors called high grade gliomas.
Methodology
Direct sequence analysis of PCR products from microdissected samples of gliomas.
Participant Demographics
19 low grade and 27 high grade glioma samples.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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