2,2′,2′′,2′′′-[Pyridine-2,6-diylbis(methylenenitrilo)]tetraethanol
2011
Crystal Structure of a Pyridine Compound
publication
Evidence: moderate
Author Information
Author(s): Cao Shou-Ying, Zhou Cheng-He
Primary Institution: Southwest University
Hypothesis
The study investigates the molecular and crystal structures of a pyridine-derived compound as an intermediate for nitrogen mustards.
Conclusion
The crystal structure reveals a closed hydrogen-bonded cage formed by the interactions of the pyridine ring and hydroxyl groups.
Supporting Evidence
- The molecule is located on a twofold axis with an asymmetric unit containing one half-molecule.
- The pyridine ring acts as a hydrogen-bond acceptor while hydroxyl groups serve as donors.
- The study contributes to the understanding of nitrogen mustards as potential antitumor agents.
Takeaway
The researchers looked at how a specific chemical compound is structured, showing how its parts stick together in a special way.
Methodology
Single crystals were grown by slow evaporation of a solution in dichloromethane and n-hexane.
Digital Object Identifier (DOI)
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