Thyroid Hormone Receptors and Skin Response to Retinoids
Author Information
Author(s): García-Serrano Laura, Gomez-Ferrería María Ana, Contreras-Jurado Constanza, Segrelles Carmen, Paramio Jesus M., Aranda Ana
Primary Institution: Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
Hypothesis
Thyroid hormone receptors (TRs) modulate the skin's response to retinoids.
Conclusion
TRs regulate skin proliferation, differentiation, and inflammation in response to retinoids, which could have therapeutic implications.
Supporting Evidence
- TR-deficient mice showed reduced hyperplasia and decreased number of proliferating cells in response to retinoids.
- Thyroid hormone binding to TRs is required for the normal response to retinoids.
- TRs modulate both the proliferative response to retinoids and their inhibitory effects on skin differentiation.
- TR KO mice exhibited increased levels of pro-inflammatory cytokines after treatment.
Takeaway
The study found that thyroid hormone receptors help control how skin reacts to certain treatments, which is important for skin health.
Methodology
The study compared the epidermal response of mice lacking TRα1 and TRβ to retinoids and TPA.
Participant Demographics
Adult female mice were used in the experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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