PD-1 and PD-L1 as Biomarkers in Colorectal Cancer
Author Information
Author(s): Rasyid Nur Rahmah, Miskad Upik Anderiani, Cangara Muhammad Husni, Wahid Syarifuddin, Achmad Djumadi, Tawali Suryani, Mardiati Mardiati
Primary Institution: Hasanuddin University
Hypothesis
High PD-1 expression on TILs and high PD-L1 expression on tumor cells are positively correlated with a higher TIL grading, which may indicate a worse prognosis in colorectal adenocarcinoma.
Conclusion
The expression of PD-1 on TILs and PD-L1 on tumor cells significantly correlates with the grading of TILs in colorectal adenocarcinoma, suggesting their potential as predictive biomarkers for therapy.
Supporting Evidence
- PD-1 expression on TILs significantly correlated with higher TIL grading (p < 0.001).
- PD-L1 expression in tumors showed an inverse correlation with TIL grading (p < 0.001).
- 83.8% of samples exhibited strong PD-1 expression on TILs.
- 88.5% of samples showed strong PD-L1 expression in tumors.
Takeaway
This study found that higher levels of PD-1 on immune cells in colorectal cancer are linked to more immune cells in the tumor, while higher levels of PD-L1 on tumor cells are linked to fewer immune cells.
Methodology
A cross-sectional design was employed to analyze 130 colorectal adenocarcinoma samples using immunohistochemistry to assess PD-1 and PD-L1 expression.
Potential Biases
The study only included samples from one center, which may limit generalizability.
Limitations
The sample size is limited, and the study's cross-sectional nature may not capture temporal dynamics of PD-1/PD-L1 expression.
Participant Demographics
Most participants were older than 50 years, with a male-to-female ratio of approximately 1.13:1.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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