Induction of Vasculogenesis in Breast Cancer Models
Author Information
Author(s): Shirakawa K, Furuhata S, Watanabe I, Hayase H, Shimizu A, Ikarashi Y, Yoshida T, Terada M, Hashimoto D, Wakasugi H
Primary Institution: National Cancer Center Research Institute
Hypothesis
Can human breast cancer lines induce proliferation of endothelial cells and endothelial precursor cells in animal models?
Conclusion
The study provides direct evidence that breast cancer induces postnatal vasculogenesis in vivo.
Supporting Evidence
- Endothelial precursor cell populations were elevated in bone marrow, peripheral blood, and tumor-infiltrating cells in all transplanted mice.
- The endothelial precursor cell population was 14% or greater in the gated lymphocyte-size fraction of the inflammatory breast cancer xenograft WIBC-9.
- Bone marrow-derived endothelial precursor cells from human breast cancer xenografts proliferated and formed clusters in vitro.
Takeaway
The study shows that breast cancer can help create new blood vessels from special cells in the body, which is important for tumor growth.
Methodology
Endothelial precursor cells were isolated from bone marrow, peripheral blood, and tumor-infiltrating cells from mice with breast cancer xenografts, and their differentiation and migration were measured.
Participant Demographics
Mice used in the study were athymic, female, ovariectomised BALBc nu/nu mice.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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