Micronutrients in Gastrointestinal Cancer
Author Information
Author(s): S.N. Georgiannos, P.M.T. Weston, A.W. Goode
Primary Institution: The Royal London Hospital Medical College
Hypothesis
The study investigates the relationship between dietary intake and micronutrient status in patients with gastrointestinal adenocarcinoma before and after surgery.
Conclusion
Weight-losing gastrointestinal cancer patients have lower levels of vitamin C and thiamine due to reduced intake and an acute phase response to their illness.
Supporting Evidence
- Weight-losing cancer patients had significantly lower plasma vitamin C and thiamine levels compared to weight-stable patients.
- Vitamin C intake was lower in weight-losing patients, correlating with their plasma levels.
- Plasma C-reactive protein was higher in weight-losing patients, indicating an acute phase response.
Takeaway
Patients with gastrointestinal cancer who are losing weight don't get enough vitamin C and thiamine, which can make them sicker.
Methodology
Patients completed a 7-day food record, and blood samples were taken to measure plasma vitamin C and thiamine levels.
Limitations
The study may not account for all factors affecting micronutrient levels in cancer patients.
Participant Demographics
31 cancer patients (18 weight-stable, 13 weight-losing) and 10 control patients with benign gastrointestinal disease.
Statistical Information
P-Value
p<0.002
Statistical Significance
p<0.05
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