Evaluating False Discovery Rate Approaches in Genetic Studies
Author Information
Author(s): Yang Qiong, Cui Jing, Chazaro Irmarie, Cupples L Adrienne, Demissie Serkalem
Primary Institution: Boston University
Hypothesis
How do Storey's FDR approach and the Bonferroni procedure compare in terms of type I error rate and power in genome-wide association studies?
Conclusion
Storey's FDR approach is more powerful than the Bonferroni procedure if strong control of FDR or weak control of FWER is desired.
Supporting Evidence
- Storey's FDR approach showed slightly better power than the Bonferroni approach.
- Storey's FDR approach had a strong control of FDR but weak control of FWER.
- The power of Storey's FDR approach was not much higher than the Bonferroni method due to low linkage disequilibrium among markers.
Takeaway
This study looked at two methods for finding genetic links to diseases and found that one method is better at finding true links without making too many mistakes.
Methodology
The study used 100 simulated datasets from the Genetic Analysis Workshop 14 to compare the type I error rate and power of Storey's FDR approach and the Bonferroni procedure.
Potential Biases
The results may be influenced by the low linkage disequilibrium among the markers used.
Limitations
The study's findings may not apply to tests with high linkage disequilibrium among markers.
Participant Demographics
The study used simulated datasets based on the Danacaa population, which included 100 nuclear families with an average of 6 members each.
Digital Object Identifier (DOI)
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