How a Protein Affects Allergic Reactions in Mice
Author Information
Author(s): Lewkowich Ian P, Day Scottie B, Ledford John R, Zhou Ping, Dienger Krista, Wills-Karp Marsha, Page Kristen
Primary Institution: Cincinnati Children's Hospital Medical Center
Hypothesis
The study investigates how protease-activated receptor 2 (PAR-2) activation in myeloid dendritic cells regulates allergic airway inflammation.
Conclusion
The study concludes that allergen activation of PAR-2 on myeloid dendritic cells is crucial for mediating Th2/Th17 cytokine production and allergic airway responses.
Supporting Evidence
- Exposure to German cockroach frass induced airway hyperresponsiveness in wild type mice.
- PAR-2-deficient mice had significantly reduced allergic responses.
- PAR-2 activation was important for Th2/Th17 cytokine production.
- Adoptive transfer of wild type BMDCs induced allergic airway inflammation.
- PAR-2-deficient BMDCs showed reduced cytokine production compared to wild type.
Takeaway
This study shows that a specific protein helps the body react to allergens, which can cause asthma-like symptoms in mice.
Methodology
Mice were sensitized with German cockroach feces and various measurements of airway inflammation and cytokine production were assessed.
Participant Demographics
Mice (wild type and PAR-2-deficient) were used in the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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