Variability of Bio-Clinical Parameters in Chinese-Origin Rhesus Macaques Infected with Simian Immunodeficiency Virus
Author Information
Author(s): Chen Song, Lai Chunhui, Wu Xiaoxiang, Lu Yaozheng, Han Daishu, Guo Weizhong, Fu Linchun, Andrieu Jean-Marie, Lu Wei
Primary Institution: Peking Union Medical College and Chinese Academy of Medical Science, Tsinghua University, Beijing, China
Hypothesis
The study aims to evaluate the bio-clinical variability of Chinese-origin Rhesus macaques infected with simian immunodeficiency virus (SIV).
Conclusion
The study provides solid estimates of variability in bio-clinical endpoints needed for designing studies using the Ch RhM SIV model.
Supporting Evidence
- All SIV-challenged Ch RhMs became seropositive for SIV within 1-2 weeks.
- Plasma viral load peaked at weeks 1-2 and then declined to set-point levels from week 5.
- The set-point viral load was 30 fold higher in SIVmac239-infected animals than in SIVmac251-infected animals.
- Rates of progression to AIDS or death were more rapid in SIVmac239-infected animals.
- Significant differences in CD4+ T-cell counts were observed between different SIV challenges.
Takeaway
Scientists studied 150 monkeys to see how a virus affects them, helping to improve future vaccine tests.
Methodology
150 Chinese-origin Rhesus macaques were randomized into three groups and challenged with different SIV strains, followed for 118 weeks.
Potential Biases
Randomization was used to control bias, but the specific MHC alleles present in the macaques could influence results.
Limitations
The study may not fully represent all variations in SIV infection due to the specific population of macaques used.
Participant Demographics
150 Chinese-origin Rhesus macaques (78 males and 72 females), aged 3-6 years.
Statistical Information
P-Value
p<0.01
Confidence Interval
95% confidence interval between 69 and 129
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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