Nutritional Benefits and Healing Properties of Lentinus squarrosulus Extract
Author Information
Author(s): Mhd Omar Nor Adila, Abdullah Noorlidah, Kuppusamy Umah Rani, Abdulla Mahmood Ameen, Sabaratnam Vikineswary
Primary Institution: University of Malaya
Hypothesis
Can Lentinus squarrosulus mycelia extract prevent and heal gastric ulcers?
Conclusion
Lentinus squarrosulus mycelia extract effectively prevents and heals gastric ulcers in rats, associated with reduced proinflammatory cytokines.
Supporting Evidence
- The extract contains high protein (57.6 g/100 g) and low total fat (0.5 g/100 g).
- Oral feeding of the extract at 250 mg/kg showed significant gastric mucosal protection.
- The ulcer healing rate was 82%, 90%, and 100% after 24, 48, and 72 hours of treatment, respectively.
- The extract significantly reduced IL-1β levels in serum.
- The extract's antioxidant capacity was demonstrated with an IC50 of 14.29 mg/mL.
Takeaway
This study shows that a mushroom extract can help heal stomach ulcers and is safe for rats, making it a potential natural remedy.
Methodology
The study involved water extraction of L. squarrosulus mycelia, followed by nutritional analysis, antioxidant capacity tests, and evaluation of antiulcer effects in Sprague-Dawley rats.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Adult male and female Sprague-Dawley rats aged 6–8 weeks.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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