Predicting Disease Activity and Joint Damage in Rheumatoid Arthritis
Author Information
Author(s): Fathi Nihal A, Ezz-Eldin Azza M, Mosad Eman, Bakry Rania M, Hamed Hosny B, Ahmed Sahar, Mahmoud Marwa, Rashed Hebat-Allah G, Abdullah Fatma
Primary Institution: Assiut University Hospital, Assiut, Egypt
Hypothesis
The study evaluates the significance of genetic and serologic markers in predicting disease activity and joint damage in rheumatoid arthritis patients.
Conclusion
Anti-CCP2 is superior to RF for detecting rheumatoid arthritis and provides predictive information on joint destruction and disease activity.
Supporting Evidence
- 83.3% of patients tested positive for anti-CCP antibodies.
- Independent predictors of disease activity included anti-CCP and DRB1*04 positive allele.
- The combination of DRB1*04 and anti-CCP antibodies increased specificity to 92%.
- Patients with HLA-DRB1*04 had a higher grade of disease activity.
Takeaway
This study found that certain blood tests can help doctors predict how severe rheumatoid arthritis will be in patients.
Methodology
The study examined 60 rheumatoid arthritis patients, measuring various blood markers and evaluating radiographic changes.
Participant Demographics
90% of participants were women, median age was 50 years.
Statistical Information
P-Value
0.001
Confidence Interval
OR 19.6 (2.1–48.5), OR 5.1 (1.2–21.1)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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