Overexpression of metastasis-associated MTA1 mRNA in invasive oesophageal carcinomas
1999
MTA1 mRNA Overexpression in Oesophageal Carcinomas
Sample size: 47
publication
Evidence: moderate
Author Information
Author(s): Toh Y, Kuwano H, Mori M, Nicolson G L, Sugimachi K
Primary Institution: National Kyushu Cancer Center
Hypothesis
Does the overexpression of MTA1 mRNA correlate with invasive characteristics in oesophageal carcinomas?
Conclusion
The study found that MTA1 mRNA overexpression is associated with higher rates of invasion and metastasis in oesophageal carcinomas.
Supporting Evidence
- MTA1 mRNA was overexpressed in 34.0% of the oesophageal carcinomas studied.
- Tumours with MTA1 overexpression had significantly higher rates of adventitial invasion.
- Lymph node metastasis was also significantly more frequent in tumours overexpressing MTA1.
Takeaway
Researchers looked at cancer samples and found that when a certain gene (MTA1) is more active, the cancer tends to spread more.
Methodology
Quantitative reverse transcription polymerase chain reaction was used to measure MTA1 mRNA levels in cancer samples.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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