Diversity of core promoter elements comprising human bidirectional promoters
2008
Understanding Human Bidirectional Promoters
Sample size: 1366
publication
Evidence: high
Author Information
Author(s): Mary Qu Yang, Laura L Elnitski
Primary Institution: National Human Genome Research Institute, National Institutes Health
Hypothesis
What are the core promoter elements that comprise human bidirectional promoters?
Conclusion
Bidirectional promoters utilize a variety of core promoter elements, with CpG-islands being the most dominant.
Supporting Evidence
- Bidirectional promoters are enriched in the genome and tend to be co-expressed.
- CpG-islands were present in 90% of bidirectional promoters compared to 45% of non-bidirectional promoters.
- The presence of TATA motifs in bidirectional promoters was lower than the genome average.
Takeaway
This study looks at special DNA regions that help start genes in two directions. It finds that certain patterns in the DNA are really important for how these genes work together.
Methodology
The study used computational analyses of large-scale experimental datasets and motif analyses to map core promoter elements.
Statistical Information
P-Value
8.38e-09
Statistical Significance
p<0.0002
Digital Object Identifier (DOI)
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