Dendritic Cell Density and Breast Cancer Survival
Author Information
Author(s): Coventry B J, Morton J
Primary Institution: University of Adelaide, Royal Adelaide Hospital
Hypothesis
What is the relationship between CD1a-positive dendritic cell density in breast cancer tissues and 5-year survival rates?
Conclusion
The study found no significant correlation between CD1a-positive dendritic cell density and 5-year survival in breast cancer patients.
Supporting Evidence
- 12 out of 48 patients died before the 5-year mark, all due to breast cancer.
- The median age at diagnosis was 60.5 years.
- CD1a density ranged from 0 to 14.85 cells per high power field, with a median of 0.78.
- Traditional prognostic factors like tumor size and lymph node status were significantly associated with survival.
Takeaway
This study looked at how many special immune cells called dendritic cells are in breast cancer tissues and if that affects how long patients live after treatment. It turns out, it doesn't seem to make a difference.
Methodology
The study analyzed fresh tissue samples from 51 female patients with breast cancer, measuring CD1a density and correlating it with 5-year survival data.
Limitations
The sample size may have limited the ability to detect significant associations.
Participant Demographics
All participants were female patients with infiltrating ductal breast carcinoma, aged 26 to 84 years.
Statistical Information
P-Value
0.331
Statistical Significance
p=0.331
Digital Object Identifier (DOI)
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