Ethanol Extract of Abnormal Savda Munziq Inhibits Colon Cancer Cell Growth
Author Information
Author(s): Yusup Abdiryim, Upur Halmurat, Umar Anwar, Berke Benedicte, Moore Nicholas
Primary Institution: Xinjiang Medical University
Hypothesis
The study aims to investigate the effect of Abnormal Savda Munziq (ASMq) ethanol extract on the proliferation and apoptosis of colon cancer cells (Caco-2).
Conclusion
The ASMq ethanol extract inhibits the growth of Caco-2 cells and induces apoptosis through cell cycle arrest and regulation of apoptosis-related gene expression.
Supporting Evidence
- ASMq ethanol extract significantly inhibited the proliferation of Caco-2 cells in a dose-dependent manner.
- Higher concentrations of ASMq ethanol extract induced apoptosis in Caco-2 cells.
- The study showed a significant increase in the sub-G1 phase of the cell cycle after treatment with ASMq ethanol extract.
Takeaway
This study found that a herbal medicine called Abnormal Savda Munziq can help stop cancer cells from growing and can make them die in a healthy way.
Methodology
Caco-2 cells were treated with different concentrations of ASMq ethanol extract, and various assays were performed to assess cell viability, DNA fragmentation, cell cycle distribution, and gene expression.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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