Thyroid Dysfunction and Insulin Resistance
Author Information
Author(s): Gabriela Brenta
Primary Institution: Dr. César Milstein Hospital
Hypothesis
The paper explores the effects of thyroid hormones on glucose metabolism and the mechanisms by which alterations in thyroid hormones lead to insulin resistance.
Conclusion
Thyroid hormones significantly impact glucose metabolism, with hyperthyroidism leading to insulin resistance primarily through hepatic mechanisms, while hypothyroidism affects peripheral tissues.
Supporting Evidence
- Hyperthyroidism is associated with increased insulin resistance due to elevated hepatic glucose output.
- Hypothyroidism can lead to insulin resistance in peripheral tissues despite lower glucose production.
- Thyroid hormones exert both insulin agonistic and antagonistic effects depending on the tissue type.
Takeaway
Thyroid hormones help control how our body uses sugar, and when they are out of balance, it can make it harder for our body to use sugar properly.
Methodology
The paper reviews existing literature and studies on the relationship between thyroid hormones and glucose metabolism.
Limitations
The paper primarily discusses findings from animal studies and may not fully represent human physiology.
Digital Object Identifier (DOI)
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