relA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells
2001
How relA Affects Tumor Growth and Cell Death in Breast Cancer
Sample size: 12
publication
Evidence: moderate
Author Information
Author(s): Ricca A, Biroccio A, Trisciuoglio D, Cippitelli M, Zupi G, Bufalo D Del
Primary Institution: Regina Elena Cancer Institute
Hypothesis
Does over-expression of the NF-kB subunit relA reduce tumorigenicity and activate apoptosis in human cancer cells?
Conclusion
Over-expression of relA reduces tumorigenicity and activates apoptosis in human cancer cells.
Supporting Evidence
- Over-expression of relA significantly reduced tumorigenic ability in nude mice.
- In vitro studies showed reduced cell proliferation after relA over-expression.
- Apoptosis was linked to increased production of reactive oxygen species.
Takeaway
When a specific protein called relA is increased in breast cancer cells, it helps stop the cancer from growing and makes the cells die.
Methodology
The study involved over-expressing the NF-kB subunit relA in MCF7 ADR human breast cancer cells and observing the effects on tumorigenicity and apoptosis in nude mice and in vitro.
Digital Object Identifier (DOI)
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