THE INTERPLAY BETWEEN GENETIC VARIANTS IN MIR146A AND ABCG2 GENES IS ASSOCIATED WITH HUMAN SURVIVAL
2024
Genetic Variants and Human Survival
publication
Evidence: moderate
Author Information
Author(s): Yashin Anatoliy, Wu Deqing, Arbeev Konstantin, Duan Hongzhe, Holmes Rachel, Akushevich Igor, Ukraintseva Svetlana
Primary Institution: Duke University
Hypothesis
The interplay between variants in miR146a and ABCG2 genes is associated with human survival.
Conclusion
The study found a significant association between specific genetic variants and human survival.
Supporting Evidence
- The analysis detected a statistically significant association of interaction between rs13120400 in the ABCG2 gene and rs2910163 in the miR146 gene.
- Interactions of rs13120400 also showed nominally statistically significant associations with two other SNPs from the miR146a gene.
- All four SNPs are well known in scientific literature and play important roles in many health and longevity-related traits.
Takeaway
This study looks at how certain genes might help people live longer. It found that some gene variations are linked to survival.
Methodology
Logistic regression model applied to Framingham Heart Study data.
Statistical Information
P-Value
3.74E-03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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