Intricate knots in proteins: Function and evolution
2006
Intricate Knots in Proteins: Function and Evolution
Sample size: 273
publication
Evidence: moderate
Author Information
Author(s): Virnau Peter, A. Mirny Leonid, Kardar Mehran
Primary Institution: Massachusetts Institute of Technology
Hypothesis
The occurrence of knots in proteins may be related to their function in protein degradation.
Conclusion
The study identifies the most complex knot in a human protein and suggests that its structure protects it from degradation.
Supporting Evidence
- The study found 273 knotted structures in the Protein Data Bank.
- The most complex knot discovered is in human ubiquitin hydrolase.
- Knots in proteins are typically preserved across species.
Takeaway
Some proteins have knots that help them stay stable and not fall apart, which is important for their job in the body.
Methodology
The study analyzed all entries in the Protein Data Bank to identify knotted structures in proteins.
Limitations
The method used may not be foolproof as differences between knotted and unknotted structures can be subtle.
Digital Object Identifier (DOI)
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