From chloroquine to artemisinin-based combination therapy: the Sudanese experience
2006

Sudan's Shift from Chloroquine to Artemisinin-based Combination Therapy

publication Evidence: high

Author Information

Author(s): Malik EM, Mohamed TA, Elmardi KA, Mowien RM, Elhassan AH, Elamin SB, Mannan AA, Ahmed ES

Primary Institution: National Malaria Control Programme, Sudan

Hypothesis

How can Sudan effectively transition from chloroquine to artemisinin-based combination therapy for malaria treatment?

Conclusion

The implementation of the new malaria treatment policy in Sudan is hindered by drug availability, high costs, and limited manufacturers.

Supporting Evidence

  • Chloroquine resistance has been documented in Sudan since the 1970s.
  • 85.6% of severe malaria patients received chloroquine before hospitalization.
  • ACTs have shown high efficacy with low failure rates in several studies.

Takeaway

Sudan is changing its malaria treatment from an old drug called chloroquine to a new combination therapy that works better, but it's hard because the new drugs are expensive and not always available.

Methodology

Data was collected from published and unpublished documents, including efficacy studies and official reports related to malaria treatment.

Limitations

The study is limited by the availability of drugs and the high costs associated with the new treatment.

Digital Object Identifier (DOI)

10.1186/1475-2875-5-65

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