Effect of Oral Clonidine on Patients Undergoing Laparoscopic Cholecystectomy
Author Information
Author(s): Shivinder Singh, Kapil Arora
Primary Institution: Armed Forces Medical College, Pune, Maharashtra, India
Hypothesis
Does oral clonidine premedication improve perioperative haemodynamic response and reduce postoperative analgesic requirements in patients undergoing laparoscopic cholecystectomy?
Conclusion
Oral clonidine premedication leads to improved haemodynamic stability and reduced need for postoperative analgesics in patients undergoing laparoscopic cholecystectomy.
Supporting Evidence
- Clonidine significantly improved haemodynamic stability during surgery.
- Patients receiving clonidine had a longer time before needing pain relief after surgery.
- Less isoflurane was needed for patients premedicated with clonidine.
Takeaway
Giving patients a pill called clonidine before surgery helps keep their heart and blood pressure steady and makes them need less pain medicine afterward.
Methodology
A randomized, single-blind study comparing 25 patients receiving oral clonidine to 25 receiving a placebo before laparoscopic cholecystectomy.
Potential Biases
Potential bias in patient selection and the single-blind design may affect the results.
Limitations
The study only included ASA grades I and II patients and may not be generalizable to other populations.
Participant Demographics
50 adult patients, ASA grades I and II, aged 20 to 60 years.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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